DOI: https://doi.org/10.21897/rmvz.1139

Neospora caninum: Relación Biológica con Toxoplasma gondii y su Potencial como Zoonosis

Neospora caninum: Biological Relationship with Toxoplasma gondii and its Potential as Zoonosis

Laura Natalia Robayo Sánchez, Jorge Enrique Gómez Marín, Jesús Alfredo Cortés Vecino

Resumen


Objetivo. Realizar una revisión sistemática de la literatura sobre el potencial zoonótico de Neospora caninum teniendo en cuenta su relación biológica con Toxoplasma gondii. Materiales y métodos. Se realizó una revisión sistemática, utilizando dos bases de datos para la recopilación de la información (Science direct y Scielo), un buscador (Google Scholar) y el Repositorio de la Universidad Nacional de Colombia, todos los documentos fueron organizados por medio del gestor bibliográfico Mendeley para su correcta revisión. Se emplearon palabras claves como “Neosporosis”, “Neospora caninum”, “Toxoplasmosis”, “Toxoplasma gondii”, “Neospora humans”, “Neospora human infection”, “Neospora zoonotic”. Se encontraron ocho documentos que cumplían el criterio de evaluar la infección en humanos.  Resultado. Se utilizaron 8 documentos concernientes al tema de Neospora en humanos, donde se evidencia en algunos de estos reportes seropositividad en muestras de humanos, empleando diferentes técnicas serológicas para la detección de anticuerpos anti- N. caninum y anti-T. gondii, pero ninguna buscó la demostración directa del parásito en tejidos (por técnicas moleculares o cultivo). Conclusiones. Ningún estudio permite concluir definitivamente si existe infección en humanos, pues se utilizaron pruebas serológicas que tiene el riesgo de reacciones cruzadas con Toxoplasma gondii, se requieren estudios que demuestren exposición, signos clínicos asociados o patologías relacionadas con esta infección. 


Palabras clave


Neospora caninum; Toxoplasma gondii; Serología; Zoonosis; Salud pública

Texto completo:

PDF

Referencias


Bjerkas I, Mohn SF, Presthus J. Unidentified cyst-forming sporozoon causing encephalomyelitis and myositis in dogs. Z Parasitenk 1984; 70:271–274. https://doi.org/10.1007/BF00942230

Baszler T V, Knowles DP, Dubey JP, Gay JM, Mathison B a, McElwain TF. Serological diagnosis of bovine neosporosis by Neospora caninum monoclonal antibody-based competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol 1996; 34(6):1423–1428.

Goodswen SJ, Kennedy PJ, Ellis JT. A review of the infection, genetics, and evolution of Neospora caninum: From the past to the present. Infect Genet Evol 2013; 13:133-150. DOI: http://dx.doi.org/10.1016/j.meegid.2012.08.012

Dubey J, Dorough K, Jenkins M, Liddell S, Speer C, Kwok OC, et al. Canine neosporosis: clinical signs, diagnosis, treatment and isolation of Neospora caninum in mice and cell culture. Int J Parasitol 1998; 28(8):1293–304. https://doi.org/10.1016/S0020-7519(98)00099-X

Shaapan RM. The common zoonotic protozoal diseases causing abortion. J Parasit Dis 2015; 40(4):1116–29. https://doi.org/10.1007/s12639-015-0661-5

Dubey JP, Lindsay DS, Lipscomb TP. Neosporosis in cats. Vet Pathol 1990; 27(5):335–9. https://doi.org/10.1177/030098589002700505

Dubey JP, Lindsay DS. A review of Neospora caninum and neosporosis. Vet Parasitol 1996; 67(1):1-59. https://doi.org/10.1016/S0304-4017(96)01035-7

Bjerkas I, Jenkins MC, Dubey JP. Identification and characterization of Neospora caninum tachyzoite antigens useful for diagnosis of neosporosis. Clin Diagn Lab Immunol 1994; 1(2):214–21.

Monteiro RM, Richtzenhain LJ, Pena HF, Souza SL, Funada MR, Gennari SM., et al. Molecular phylogenetic analysis in Hammondia-like organisms based on partial Hsp70 coding sequences. Parasitology 2007; 134(Pt9):1195-203. https://doi.org/10.1017/S0031182007002612

Howe DK, Sibley LD. Development of molecular genetics for Neospora caninum: A complementary system to Toxoplasma gondii. Methods 1997; 13(2):123–33. https://doi.org/10.1006/meth.1997.0505

Howe DK, Mercier C, Messina M, Sibley LD. Expression of Toxoplasma gondii genes in the closely-related apicomplexan parasite Neospora caninum. Mol Biochem Parasitol 1997; 86(1):29-36. https://doi.org/10.1016/S0166-6851(97)90003-7

Dubey J. Neosporosis—the first decade of research. Int J Parasitol 1999; 29(10):1485-8. https://doi.org/10.1016/S0020-7519(99)00134-4

Dubey JP. Recent advances in Neospora and neosporosis. Vet Parasitol 1999; 84(3):349–67. https://doi.org/10.1016/S0304-4017(99)00044-8

Okeoma CM, Stowell KM, Williamson NB, Pomroy WE. Neospora caninum: quantification of DNA in the blood of naturally infected aborted and pregnant cows using real-time PCR. Exp Parasitol 2005; 110(1):48-55. doi:10.1016/j.exppara.2005.01.008

Barr BC, Conrad PA, Sverlow KW, Tarantal AF, Hen- drickx AG. Experimental fetal and transplacental Neospora infection in the nonhuman primate. Lab Investig 1994, 71(2):236-42.

Vargas JJ, Cortés JA. 2001. Neospora caninum,¿Una Zoonosis Potencial?. Rev Salud Pública 2001; 3(1):89-93

Ho-Woo N, Seung-Wong K, Won-Young C. Antibody reaction of human anti-Toxoplasma gondii positive and negative sera with Neospora caninum antigens. Korean J Parasitol 1998; 36(4):269-75 https://doi.org/10.3347/kjp.1998.36.4.269

Petersen E, Lebech M, Jensen L, Lind P, Rask M, Bagger P, Björkman C, Uggla A. Neospora caninum Infection and Repeated Abortions in Humans. Emerg Infect Dis 1999; 5(2):278-80. https://doi.org/10.3201/eid0502.990215

Tranas J, Heinzen RA, Weiss LM, Mcallister MM. Serological Evidence of Human Infection with the Protozoan Neospora caninum. Clin Diagn Lab Immunol 1999; 6(5):765-67.

Lobato J, Silva DAO, Tiago WPM, Amaral JDHF, Silva-Segundo GR, Costa-Cruz JM, Ferreira MS, Borges AS, Mineo JR. Detection of Immunoglobulin G Antibodies to Neospora caninum in Humans: High Seropositivity Rates in Patients Who Are Infected by Human Immunodeficiency Virus or Have Neurological Disorders. Clin Vaccine Immunol 2006; 13(1):84-89. doi:10.1128/CVI.13.1.84–89.2006 https://doi.org/10.1128/CVI.13.1.84-89.2006

McCann CM, Vyse AJ, Salmon RL, Thomas D, Williams DJL, Mc Garry JW, Pebody R, Trees AJ. Lack of Serologic Evidence of Neospora caninum in Humans England. Emerg Infect Dis 2008; 14(6):978-980. https://doi.org/10.3201/eid1406.071128

Gangneux FR, Klein F. Serologic Screening for Neospora caninum, France. Emerg Infect Dis 2009; 15(6):987. doi: 10.3201/eid1506.081414 https://doi.org/10.3201/eid1506.081414

Benetti AH, Schein FB, Dos Santos TR, Toniollo GH, Da Costa AJ, Mineo JR, Lobato J, De Oliveira Silva A, Gennari SM. Pesquisa de anticorpos anti-Neospora caninum em bovinos leiteiros, cães e trabalhadores rurais da região Sudoeste do Estado de Mato Grosso. Rev Bras Parasitol Vet 2009; 18(1):29-33. doi:10.4322/rbpv.018e1005 https://doi.org/10.4322/rbpv.018e1005

Carvalho JV, Alves CMOS, Cardoso MRD, Motaa CM, Barbosa BF, Ferro EAV, Silva NM, Mineoa TWP, Silva DAO. Differential susceptibility of human trophoblastic (BeWo) and uterine cervical (HeLa) cells to Neospora caninum infection. Int J Parasitol 2010; 40:1629–1637. https://doi.org/10.1016/j.ijpara.2010.06.010

Torgerson PR, Macpherson CNL. The socioeconomic burden of parasitic zoonoses: Global trends. Vet Parasitol 2011; 182:79-95. doi:10.1016/j.vetpar.2011.07.017 https://doi.org/10.1016/j.vetpar.2011.07.017

Weiss LM, Ma YF, Halonen S, McAllister MM, Zhang YW. The in vitro development of Neospora caninum bradyzoites. Int J Parasitol 1999; 29:1713–23. https://doi.org/10.1016/S0020-7519(99)00130-7

Sundermann CA, Estridge BH. Growth of and competition between Neospora caninum and Toxoplasma gondii in vitro. Int J Parasitol 1999; 29:1725–32. https://doi.org/10.1016/S0020-7519(99)00114-9

Omata Y, Kano R, Masukata Y, Kobayashi Y, Igarashi M, Maeda R, et al. Development of Neospora caninum cultured with human serum in vitro and in vivo. J Parasitol 2005; 91:222–25. https://doi.org/10.1645/GE-3364-RN

Lv Q, Li J, Gong P, Xing S, Zhang X. Neospora caninum: In vitro culture of tachyzoites in MCF-7 human breast carcinoma cells. Exp Parasitol 2010; 126:536-39 https://doi.org/10.1016/j.exppara.2010.06.006

Gondim LF1, Mineo JR2, Schares G3. Importance of serological cross-reactivity among Toxoplasma gondii, Hammondia spp., Neospora spp., Sarcocystis spp. and Besnoitia besnoiti. Parasitology 2017; 28:1-18. https://doi.org/10.1017/S0031182017000063

McAllister MM, Dubey JP, Lindsay DS, Jolley WR, Wills RA, McGuire, AM. Dogs are definitive hosts of Neospora caninum. Int J Parasitol 1998; 28:1473–78. https://doi.org/10.1016/S0020-7519(98)00138-6

Dubey JP. Review of Neospora caninum and neosporosis in animals. Korean J Parasitol 2003; 41:1-16. https://doi.org/10.3347/kjp.2003.41.1.1


Métricas de artículo

Cargando métricas ...

Metrics powered by PLOS ALM

Enlaces refback

  • No hay ningún enlace refback.


Copyright (c) 2017 Revista MVZ Córdoba

Licencia de Creative Commons
Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional.