Sistematización de la prevalencia de Anaplasma spp., en caninos y metanálisis de A. platys y A. phagocytophilum

Contenido principal del artículo

Autores

Jaiberth Antonio Cardona Arias http://orcid.org/0000-0002-7101-929X Juliana Zapata Marín http://orcid.org/0000-0002-8555-4218 Johanna Marcela Urán Velásquez http://orcid.org/0000-0003-0187-4917

Resumen

Objetivo. Estimar la prevalencia general de Anaplasma spp. y la prevalencia específica de A. platys y A. phagocytophilum en caninos, mediante estudios publicados entre 2000 y 2018. Materiales y métodos. Revisión sistemática con 14 estrategias de búsqueda, garantizando exhaustividad y reproducibilidad en fases de la guía PRISMA. Se evaluó la calidad con STROBE. Se calcularon frecuencias y se estimó la prevalencia global y las específicas según país, periodo y prueba diagnóstica, con sus intervalos de confianza del 95%. Se realizó Forest Plot para la prevalencia individual y global de A. platys o A. phagocytophilum según PCR, ELISA e IFI, las cuales se compararon con base en el Estadístico Z. Resultados. Se incluyeron 30 estudios con 18.472 caninos, la mayoría de Brasil, Estados Unidos y Alemania. En IFI se halló una prevalencia de 39.0% (IC95%= 37.0-41.0), en ELISA 9.3% (IC95%= 8.8-9.8) y en PCR 7.1% (IC95%= 6.4-7.8). La prevalencia basada en PCR fue estadísticamente mayor en América con 11.9% (IC95%=10.5-13.3) frente a África con 5.5% (IC95%=1.2-9.7), Asia 4.1% (IC95%=3.1-5.1) y Europa 3.5% (IC95%=2.5-4.5). La prevalencia de A. platys con PCR fue 16.1% (IC95%=14.2-17.9) y de A. phagocytophilum 3.7% (IC95%= 2.8-4.6). Conclusiones. Se halló una elevada prevalencia de infección, con mayor importancia de A. platys, en un bajo número de publicaciones en el ámbito mundial y con una elevada heterogeneidad según el país, la técnica diagnóstica y la especie implicada.

Palabras clave:

Detalles del artículo

Referencias

1. Carrade D, Foley J, Borjesson D, Sykes J. Canine granulocytic Anaplasmosis: a review. J Vet Intern Med. 2009; 23(6):1129-1141. https://doi.org/10.1111/j.1939-1676.2009.0384.x

2. Dolz G, Ábrego L, Romero L, Campos L, Bouza L, Jiménez A. Ehrlichiosis and anaplasmosis in Costa Rica. Acta Méd Costarric. 2013; 55(Suppl. 1): 34-40. https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0001-60022013000400008

3. Pujalte G, Marberry S, Libertin C. Tick-Borne Illnesses in the United States. Prim Care. 2018; 45(3):379-391. https://doi.org/10.1016/j.pop.2018.05.011

4. Soto K. Determinación de la prevalencia de anaplasmosis en el ganado bovino faenado en la empresa Metropolitana de Rastro de Quito mediante la aplicación de las técnicas de diagnóstico: microscopía de frotis sanguíneos, PCR y cELISA. Ecuador: Escuela Politécnica del Ejército, Ingeniería en Biotecnología; 2010. http://repositorio.espe.edu.ec/handle/21000/2846

5. Mateus T, Castro A, Ribeiro J, Vieira M. Multiple Zoonotic Parasites Identified in Dog Feces Collected in Ponte de Lima, Portugal - A Potential Threat to Human Health. Int J Environ Res Public Health. 2014; 11(9):9050–9067. https://doi.org/10.3390/ijerph110909050

6. Troncoso I, Fisher C, Villarroel C, Herzberg D. Case report: Anaplasma phagocytophilum in a dog. Hospitales veterinarios. 2014, 6(2):41-46. http://www.rhv.cl/index.php?option=com_docman&task=doc_download&gid=83&Itemid=

7. Berzina I, Krudewig C, Silaghi C, Matise I, Ranka R, Müller N, et al. Anaplasma phagocytophilum DNA amplified from lesional skin of seropositive dogs. Ticks Tick Borne Dis. 2014; 5(3):329-35. https://doi.org/10.1016/j.ttbdis.2013.12.010

8. Stuen S, Granquist EG, Silaghi C. Anaplasma phagocytophilum a widespread multi-host pathogen with highly adaptive strategies. J Front Cell Infect Microbiol. 2013; 22:3-31. https://doi.org/10.3389/fcimb.2013.00031

9. Greene C, Enfermedades infecciosas del perro y el gato. 3ed. Buenos Aires: Argentina; 2008.

10. Gaunt S, Beall M, Stillman B, Lorentzen L, Diniz P, Chandrashekar R, Breitschwerdt E. Experimental infection and co-infection of dogs with Anaplasma platys and Ehrlichia canis: hematologic, serologic and molecular findings. Parasit Vectors. 2010; 3(1):1-10. https://doi.org/10.1186/1756-3305-3-33

11. Vargas G, Rogerio M, Cendales D, Gonçalves L, Hoeppner M, et al. Molecular detection of Anaplasma species in dogs in Colombia. Rev Bras Parasitol Vet. 2016; 25(4):459-464. https://doi.org/10.1590/s1984-29612016066

12. Carelli G, Decaro N, Lorusso A , Elia G , Lorusso E , Mari V, et al. Detection and quantification of Anaplasma marginale DNA in blood samples of cattle by real-time PCR. Vet Microbiol. 2007; 124(1):107-114. https://doi.org/10.1016/j.vetmic.2007.03.022

13. Pérez R, Fernández P, Encinas A. Garrapatas y anaplasmosis granulocítica humana. Rev Ibérica Parasitología. 2006; 66(1):17-29. http://bibliotecavirtual.ranf.com/es/catalogo_imagenes/grupo.cmd?path=1001734

14. Oteo J, Brouqui P. Ehrlichiosis and human anaplasmosis. Enferm Infecc Microbiol Clin. 2005; 23(6):375-380. https://doi.org/10.1157/13076178

15. González de Dios J. Revisión sistemática y metanálisis (I): conceptos básicos. Evid Pediatr. 2007; 3(4):107. https://evidenciasenpediatria.es/articulo/5204/revision-sistematica-y-metaanalisis-i-conceptos-basicos

16. Huang H, Unver A, Perez M, Orellana N, Rikihisa Y. Prevalence and molecular analysis of Anaplasma platys in dogs in Lara, Venezuela. Braz J Microbiol. 2005; 36(3):211-216. https://doi.org/10.1590/s1517-83822005000300002

17. Barutzki D, De Nicola A, Zeziola M, Reule M. Seroprevalence of Anaplasma phagocytophilum infection in dogs in Germany. Berl Munch Tierarztl Wochenschr. 2006; 119(7-8):342-347. https://www.ncbi.nlm.nih.gov/pubmed/17009720

18. Levi O, Waner T, Baneth G, Keysary A, Bruchim Y, Silverman J, Harrus S. Seroprevalence of Anaplasma phagocytophilum among healthy dogs and horses in Israel. J Vet Med. 2006; 53(2):78-80. https://doi.org/10.1111/j.1439-0450.2006.00911.x

19. Solano L, Trotta M, Razia L, Furlanello T, Caldin M. Molecular survey of Ehrlichia canis and Anaplasma phagocytophilum from blood of dogs in Italy. Ann N Y Acad Sci. 2006; 1078:515-518. https://doi.org/10.1196/annals.1374.101

20. Jensen J, Simon D, Escobar H, Soller J, Bullerdiek J, Beelitz P, et al. Anaplasma phagocytophilum in dogs in Germany, Alemania. Zoonoses Public Health. 2007; 54(2):94-101. https://doi.org/10.1111/j.1863-2378.2007.01028.x

21. Beall M, Chandrashekar R, Eberts MD, Cyr KE, Diniz PP, Mainville C, et al. Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota. Vector Borne Zoonotic Dis. 2008; 8(4):455-464. https://doi.org/10.1089/vbz.2007.0236

22. M’ghirbi Y, Ghorbel A, Amouri M, Nebaoui A, Haddad S, Bouattour A. Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. Tunez. Parasitol Res. 2009; 104(4):767-74. https://doi.org/10.1007/s00436-008-1253-4

23. Pantchev N, Schaper R, Limousin S, Norden N, Weise M, Lorentzen L. Occurrence of Dirofilaria immitis and tick-borne infections caused by Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis in domestic dogs in France: results of a countrywide serologic survey. Parasitol Res. 2009; 105 (Suppl. 1):101-114. https://doi.org/10.1007/s00436-009-1501-2

24. Barber R, Li Q, Diniz P, Porter B, Claiborne M, Levine J, et al. Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases). J Vet Intern Med. 2010; (2):372-378. https://doi.org/10.1111/j.1939-1676.2009.0466.x

25. Sakamoto L, Ichikawa Y, Sakata Y, Matsumoto K, Inokuma H. Detection of Anaplasma bovis DNA in the peripheral blood of domestic dogs in Japan. Jpn J Infect Dis. 2010; 63(5):349-52. https://www.ncbi.nlm.nih.gov/pubmed/20859003

26. Carrade D, Foley J, Sullivan M, Foley C, Sykes J. Spatial distribution of seroprevalence for Anaplasma phagocytophilum, Borrelia burgdorferi, Ehrlichia canis, and Dirofilaria immitis in dogs in Washington, Oregon, and California. Vet Clin Pathol. 2011; 40(3):293-302. https://doi.org/10.1111/j.1939-165x.2011.00334.x

27. Kohn B, Silaghi C, Galke D, Arndt G, Pfister K. Infections with Anaplasma phagocytophilum in dogs in Germany. Res Vet Sci. 2011; 91(1):71-6. https://doi.org/10.1016/j.rvsc.2010.08.008

28. Barth C, Straubinger R, Sauter-Louis C, Hartmann K. Prevalence of antibodies against Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum and their clinical relevance in dogs in Munich, Germany. Berl Munch Tierarztl Wochenschr. 2012; (7-8):337-44. https://www.ncbi.nlm.nih.gov/pubmed/22919928

29. Cardoso L, Mendão C, Madeira de Carvalho L.Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal--a national serological study Portugal. Parasit Vectors. 2012; 5(62):1-9. https://doi.org/10.1186/1756-3305-5-62

30. da Silva G, Benitez A, Girotto A, Tarod A, Vidotto M, Garcia J, Freitas J, Headley S, Vidotto O. Occurrence of Ehrlichia canis and Anaplasma platys in household dogs from northern Parana. Rev Bras Parasitol Vet. 2012; 21(4):379-85 https://doi.org/10.1590/s1984-29612012005000009

31. Mircean V, Dumitrache M, Györke A, Pantchev N, Jodies R, Cozma V, el al. Seroprevalence and geographic distribution of Dirofilaria immitis and tick-borne infections (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, and Ehrlichia canis) in dogs from Romania Vector Borne Zoonotic Dis. 2012; 12(7):595-604. https://doi.org/10.1089/vbz.2011.0915

32. Xia Z, Yu D, Mao J, Zhang Z, Yu J. The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs in China. J Helminthol. 2012; 86(2):185-189. https://doi.org/10.1017/s0022149x11000198

33. Berzina, I. Matise I. Seroprevalence against Borrelia burgdorferi sensu lato and occurence of antibody co-expression with Anaplasma phagocytophilum in dogs in Latvia. Ir Vet J. 2013; 66(1):1-3. https://doi.org/10.1186/2046-0481-66-9

34. Costa L, Rembeck K, Passos L, Ribeiro M. Factors associated with epidemiology of Anaplasma platys in dogs in rural and urban areas of Minas Gerais State, Brazil, Preventive Veterinary Medicine. 2013; 109(3-4):321-326. https://doi.org/10.1016/j.prevetmed.2012.10.011

35. Ebani V, Bertelloni F, Turchi B, Cerri D. Serological and molecular survey of Anaplasma phagocytophilum in Italian hunting dogs. Ann Agric Environ Med. 2013; 20(2):289-292. https://www.ncbi.nlm.nih.gov/pubmed/23772578

36. Lasta C, Do Santos A, Messick J, Oliveira S, Biondo A, Viera R, et al. Molecular detection of Ehrlichia canis and Anaplasma platys in dogs in Southern Brazil. Rev Bras Parasitol Vet. 2013; 22(3):360-366. https://doi.org/10.1590/s1984-29612013000300007

37. Santos A, Thome S, Baldani C, Silva C, Peixoto M, Pires M, et al. Molecular epidemiology of the emerging zoonosis agent Anaplasma phagocytophilum (Foggie, 1949) in dogs and ixodid ticks in Brazil. Parasit Vectors. 2013; 11(6):348-358. https://doi.org/10.1186/1756-3305-6-348

38. Volgina N, Romashov B, Romashova N, Shtannikov A. Prevalence of borreliosis, anaplasmosis, ehrlichiosis and Dirofilaria immitis in dogs and vectors in Voronezh Reserve (Russia) Reserva Voronezh, Comp Immunol Microbiol Infect Dis. 2013; 36(6):567-574. https://doi.org/10.1016/j.cimid.2013.08.003

39. Krämer F, Schaper R, Schunack B, Połozowski A, Piekarska J, Szwedko A, et al. Serological detection of Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato and Ehrlichia canis antibodies and Dirofilaria immitis antigen in a countrywide survey in dogs in Poland. Parasitol Res. 2014; 113(9):3229–3239. https://doi.org/10.1007/s00436-014-3985-7

40. Lanza M, Zieger U, Qurollo B, Hegarty B, Pultorak E, Kumthekar S, et al. Intraoperative bleeding in dogs from Grenada seroreactive to Anaplasma platys and Ehrlichia canis. J Vet Intern Med. 2014; 28(6):1702-1707. https://doi.org/10.1111/jvim.12442

41. McCown, M, Monterroso V, Cardona W. Surveillance for Ehrlichia canis, Anaplasma phagocytophilum, Borrelia burgdorferi, and Dirofilaria immitis in Dogs From Three Cities in Colombia. J Spec Oper Med. 2014; 14(1): 86-90. https://doi.org/10.1007/s00436-018-6033-1

42. Santamaria A, Calzada J, Saldaña A, Yabsley M, Gottdenker N. Molecular diagnosis and species identification of Ehrlichia and Anaplasma infections in dogs from Panama, Central Americ. Vector Borne Zoonotic Dis. 2014; 14(5):368-370. https://doi.org/10.1089/vbz.2013.1488

43. Dahmani M, Marié J, Mediannikov O, Raoult D, Davoust B. First identification of Anaplasma platys in the blood of dogs from French Guiana. Vector Borne Zoonotic Dis. 2015; 15(2):170-172. https://doi.org/10.1089/vbz.2014.1720

44. Dahmani M, Loudahi A, Mediannikov O, Fenollar F, Raoult D, Davoust B. Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from Kabylie, Algeria Ticks Tick Borne Dis. 2015; 6(2):198-203. https://doi.org/10.1016/j.ttbdis.2014.12.007

45. Yuasa Y, Tsai Y, Chang C, Hsu T, Chou C. The prevalence of Anaplasma platys and a potential novel Anaplasma species exceed that of Ehrlichia canis in asymptomatic dogs and Rhipicephalus sanguineus in Taiwan. J Vet Med Sci. 2017; 79(9):1494-1502. https://doi.org/10.1292/jvms.17-0224

46. Párraga M, Gonzatti M, Aso P. Diagnosis of Venezuelan Equine Anaplasmosis by Polymerase Chain Reaction. Revista Científica, FCV-LUZ. 2016; 26(6):366-373. http://www.saber.ula.ve/bitstream/handle/123456789/43191/articulo3.pdf?sequence=1&isAllowed=y

47. Corona B, Rodriguez M, Martinez S. Anaplasmosis Bovina. Revista electrónica RedVet. 2004; 6(4):1-27. http://www.veterinaria.org/revistas/redvet/n040405/040511.pdf

48. Corona González B, Obregón D, Alemán Y, Alfonso P, Vega E, Díaz A, Martinez S. Tendencias en el diagnóstico de la anaplasmosis bovina. Rev Salud Anim. 2014; 36(2):73-79. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0253-570X2014000200001

Descargas

La descarga de datos todavía no está disponible.