Determinación de marcadores inflamatorios y anabólicos articulares en caballos jóvenes estabulados con osteocondrosis tarsocrural

Contenido principal del artículo

Autores

Jorge Carmona Catalina López Marta Prades

Resumen

Objetivo. Describir los valores de las concentraciones en líquido sinovial (LS) de prostaglandina E2 (PGE2), óxido nítrico (NO), ácido hialurónico (HA) y proteína total (PT) en caballos jóvenes estabulados con osteocondrosis (OC) tarsocrural y correlacionar los valores de estos marcadores con el recuento total de células del LS, el grado de efusión sinovial (ES) y con el grado de cojera (GC). Materiales y métodos. Las concentraciones en LS de PGE2 fueron determinadas mediante ELISA, las de NO fueron valoradas por la reacción de Greiss, las de HA fueron medidas con radioinmunoanálisis RIA y las de PT mediante refractometría. Resultados. Once caballos entre 8 y 36 meses fueron incluidos. La mediana y el rango (R) de los grados de ES y GC fueron de 1.5 (R: 0.5-2) y 0 (R: 0-2), respectivamente. La mediana de la concentración de PGE2 y NO, respectivamente fue 130.6 pg/mL (R: 41-231.7 pg/mL) y 2.92 mM (R: 1.3-6.3 mM).. La concentración de HA presentó una mediana de 312.4 mg/mL (R: 70-543.5 mg/mL). La concentración promedio de PT fue de 1.2±-0.36 g/dL. Se observó correlación negativa estadísticamente significativa entre las concentraciones sinoviales de HA y el grado de efusión sinovial (ñ=-0.7; p= 0.048) y el grado de cojera (ñ=-0.78; p=0.014). Conclusiones. La concentración de HA en LS de caballos con OC podría estar negativamente correlacionada con la gravedad de los signos clínicos.

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Referencias

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